Driving directions between Tupelo, AR and Knoxville, AR. Estimated driving time is , with an average speed of about 48 miles per hour. If you want more accurate directions from your actual position or to a certain place or street, you may search street or place names directly.
You can check and book hotels in Knoxville and print the directions by clicking on the green button.
Find the directions listed below in order to go from Tupelo, AR to Knoxville, AR by car. You can click each direction to see them in the map.
US 64 $west; US 67 $south; US 167 $south; Future I 57, I 40
145.9 mi2 hours 40 mins
| Head east on 1st Street | 100 feet | |
| Turn left onto Hwy 17 | 300 feet | |
| Turn left onto AR 33 | 1.2 mi | |
| Continue onto SR 33 | 11.0 mi | |
| Turn right onto Shell Street (US 64) | 3.3 mi | |
| Continue onto United States Highway 64 (US 64) | 9.5 mi | |
| Take the ramp on the left onto US 64 W | 27.1 mi | |
| Take the ramp towards US 67B North: Beebe | 0.4 mi | |
| Keep right towards US 64 West: Conway | 32.5 mi | |
| Take the ramp | 0.4 mi | |
| Merge left onto I 40 | 59.6 mi | |
| Take the ramp towards AR 315: Knoxville | 900 feet | |
| Turn left | 100 feet | |
| Turn left onto Hwy 315 | 0.6 mi | |
| You have arrived at your destination, on the left |